NATURAL DIABETES TREATMENTS E BOOK
January 5th, 2010 | 
Author: 
Our hope is that through this web site and our controlling diabetes for life E Book That we can be of help to you, to support you in your search for information and natural diabetes treatments.
Diabetes, the disease which was once considered the wealthy man’s burden, is no longer affiliated to the rich. It has become a common malady that is spreading its vicious tentacles far and wide day by day. It is a major abetting factor for heart attacks, kidney failures and stroke. As time goes, diabetes causes vision impairment too. Controlling diabetes for life has become increasingly harder as more and more people struggle with diet’s and obesity.
The complexity of diagnosis of natural diabetes treatments is further increased by the various types of diabetes and the exclusive medication required for each type. Type 1 diabetes is caused by the inability of the body to produce insulin altogether which results in increased blood sugar levels because insulin aids in the proper dissipation of glucose into the blood. This type necessitates total dependence on insulin injections. The other type of diabetes, type 2 is the most commonly occurring form of the disease. It is caused by the insulin deficiency and the failure of the body to utilize the insulin secreted by pancreas. The stark effect of this is obesity and is easier to control with natural diabetes treatments.
We cannot feel relieved by the fact that type 2 is not as bad as type 1 because, type 2 gradually morphs into type 1 diabetes as we age and our immune system becomes weak and ultimately results in total dependence on insulin. The ray of hope in this case is that with proper exercise, healthy lifestyle and balanced diet, the type 2 diabetes can be controlled. Herbal alternatives are most sought after, due to their very minimal side effects. Cinnamon is considered as the herbal panacea for the type 2 diabetes because of its ability to reduce LDL cholesterol and glucose. Research has shown that a daily intake of minimum 1g of cinnamon reduces the serum glucose level significantly in the long run.
To understand the effectiveness of cinnamon for a natural diabetes treatments it is essential to understand the factors that increase the blood sugar levels. Heavy consumption of unsaturated fatty acids, in other words, hydrogenated oils result in clogging of arteries with cholesterol which makes the cell wall and artery passage thin, preventing the glucose from reaching the cells. The key substance in cinnamon, methylhydroxy-chalcone polymer (MHCP) , reduces this cholesterol level resulting in better absorption of glucose. It also improves the ability of the fat cells to respond to insulin which is a key benefit for type 2 diabetes. Diabetes also triggers multiple undesirable effects. One such defect is the malabsorption of necessary salts. One such salt whose absorption is prevented is magnesium. Cinnamon is a vital source of magnesium, hence supplementing our body with the necessary nutrients. MHCP in cinnamon reduce the insulin resistance in our body and triggers the insulin receptor tyrosine kinase.
Excessive quantities of anything result in negative effect. The research world is polarized on the benefits of cinnamon in reducing blood sugar levels. A particular research even says that MHCP is just a water-soluble polymer and does not have any additional qualities. The side-effects of cinnamon are mostly restricted to a specific set of conditions and there are no definite side effects affecting everybody. Studies have shown that excessive usage of cinnamon results in oral erythema multiforme which is lip swelling and mouth ulcer. It is not advisable for persons with haemophilic problems because its anti-clotting properties will cause profuse bleeding. Due to this reason, cinnamon intake is not recommended during menstruation too. Cinnamon is also a common allergy food so it cannot be recommended for everyone. For others cinnamon is a vital part of a effective natural diabetes treatments plan.
It is proven that cinnamon is greatly beneficial for people suffering from type 2 diabetes and its side effects are pronounced only in specific conditions of health like pregnancy. But it is always recommended and advised to consult the physician before trying out alternative remedy or starting any natural diabetes treatments.
Fast Tube by Casper
Our Natural Diabetes Treatments E Book Controlling Diabetes For life
Reverse Your Diabetes With Our Natural Diabetes Treatments E Book
Our hope is that through this web site and our controlling diabetes for life E Book That we can be of help to you, to support you in your search for ideas and information on diabetes.
I have type 2 diabetes. I have had it since early 1998, when I found out I had it. I would like to share the things I have found useful to me. As many people I was surprised to find I had diabetes. Some of the first things I did was research what it was and how to deal with it.
I found that I was able through watching my diet, (cutting out sugars type of diet) and moderate exercise I could have normal sugar levels. I was able to lose about 60 pounds and that did help a lot.
I have been able to control the diabetes through diet, exercise, and taking cinnamon. With proper diet and weight loss (if you need to lose weight), and exercise you too can improve your blood sugar.
When you are dealing with diabetes you need to always follow your Doctor’s advice and instructions,
we are here to share what has worked for me, and others in hopes to help you reach the diabetic goals in your life.
AVAILABLE NOW
MY COMPREHENSIVE E BOOK ON HOW TO CONTROL YOUR DIABETES FOR LIFE WITH DIET, EXERCISE AND NATURAL HERBS.
CONTROLLING TYPE 2 HIGH DIABETES FOR LIFE THROUGH NATURAL DIABETES TREATMENTS
Despite of the fact that diabetes is growing at an incredibly very fast rate (due to the drastic increase in the amount of people who are obese), scientists still have not successfully developed a treatment that would permanently eliminate the cause of this disease. Recently, however, there has been some serious talk about an natural herb diabetes treatments. But as of yet, there is still no scientific research to prove such claims. However, using herbs to help manage diabetes is gaining popularity.
Once only talked about among alternative health practitioners, the use of diabetes natural herb treatments is finally being considered by mainstream physicians. One of the most discussed herbal treatments for diabetes involves the injestion of curry leaves. On an average, it is recommended that one must have 7-8 curry leaves in the morning before having breakfast. Curry contains active ingredients that some say help stabilize blood sugar levels throughout the day.
Another herb that has been given to diabetics is Amla. This herb is a very strong ingredient that can defend your body against diabetes because like curry, it helps better manage changes in blood glucose levels. Alternative medicine practitioners suggest mixing equal parts of Alma, with the herbs jumbal and bitter gourd to get the maximum effect. Dosage recommendations are one to two tablespoons each day.
Another “herb” found in your kitchen that is showing promise in treating diabetes is garlic. Unlike some of the other herbs listed, garlic has been studied for decades by researchers and new diseases that it can treat are being discovered all of the time. One or two cloves a day goes a long way in better preparing your body in dealing with the long term negative effects caused by this disease.
One major benefit of using herbal treatments for diabetes is that they are easily available and generally inexpensive (and drastically cheaper than any medication that’s normally prescribed). Although there is no herbal cure for diabetes, more traditional doctors are realizing their effectiveness at assisting in the management of blood sugar levels and overall health
Natural herbs are a effective way of controlling your diabetes for life.
NATURAL HERB DIABETES TREATMENTS – CONTROLLING YOUR TYPE 2 DIABETES FOR LIFE
Home remedies or natural treatment type 2 diabetes catch the attention of the people due to a lot of reasons. The herbal medicines are extracted naturally from fruits, vegetables and are proved to be devoid of any side effects. Many of them are simple to be made at home and low-priced.
Herbs are medicinal plants in our surroundings that offer cure for many diseases. Modern medicines too identify many herbs as their origin. Since the ancient times, the mainstay of diabetes treatment has been herbal medicines. Researchers are going on to find the effectiveness of herbs in treating high diabetes, and recent findings show that many are evidently effective.
People who are on insulin supplements have little use with the herbal treatments for diabetes. The working mechanism of the herbs is by enhancing the action of the innate insulin produced in the body. So those faced with the problem of insulin depletion will not gain much from the natural treatments. Along with the herbal treatment mode, proper exercise and maintaining the diet are very good measures to keep the blood sugar under control.
Herbal diabetes treatment for diabetes was prevalent in the Asian countries like China. The natural herb Ginseng has been found to be a wonderful remedy for diabetes. There are around eleven Ginseng species found exclusively in the Asian countries. They are thick-rooted perennial plants whose roots can be dried easily. The root of one of the species, Panax, is available across the world in the dried form.
Some of the popular herbs that are used in the treatment of diabetes include:
- Aloe Vera, the wonderful herb is valuable in diabetes control also. The gel inside the aloe leaves are used for the treatment.
- The bark of the plant Pterocarpus marsupium has the unique ability among all the herbs by promoting the regeneration of beta cells in the pancreas.
- The commonly found onions and garlic increases the insulin production and lower the blood sugar.
- Fenugreek seeds are also found to possess anti diabetic properties.
- The decoction of the blueberry leaves has proven efficacy in bringing down the blood sugar level.
- Bitter gourd, especially the seeds of them help to reduce the blood sugar.
- Gymnema is another herb that aids in insulin production. Even though many studies have not been conducted, the plant is found to be effective in controlling both type I and type II diabetes.
- Cinnamon bark is effective in converting the fat cells to glucose and then to energy. It facilitates the action of insulin on the fat cells in the body and is one of the best herbal diabetes treatments.
- Turmeric, mango leaves, curry leaves, gooseberry, ispaghula etc are other useful herbs to control diabetes.
For Anyone with type 2 diabetes these natural herbs and others are a effective way of controlling your diabetes for life.
Due to the difficulty involved in identifying and using the herbs in various forms, many of the herbal medicines are formulated in to tablets, powders and other forms. This will ensure the supply of medicines and supplements to different parts of the world.
Why Is Your Blood Sugar Level Higher In The Morning
Why is Your Blood Sugar Level Higher in the Morning?
By Beverleigh H Piepers
Too much insulin causes low blood sugar levels or hypoglycemia and because this is a life-threatening situation, your body will respond by releasing several insulin antagonists… cortisol and epinephrine from your adrenal glands, growth hormone from the pituitary gland and glucagon from your pancreas. Why… to negate the effects of insulin.
These are very powerful hormones that bring about rapid and powerful elevations in your blood sugar levels and often cause your blood sugars to shoot too high. So then these high levels need to be treated with more insulin which can then cause another plunge in your blood glucose. This will be followed by another compensatory response and even larger doses of insulin.
Now the Dawn Phenomenon is a natural occurring process that occurs during the sleep cycle, where your body starts to work on the compensatory response mentioned above. These hormones fight against your insulin’s attempt to lower your blood sugars, and usually occurs when your insulin dose is wearing off. This results in your high blood sugars in the morning. This occurs in many type 2 diabetics six to ten hours after bedtime.
Many people with type 2 diabetes wake up in the morning with a higher blood sugar level than when they went to bed, although they have not eaten and had their insulin injection or anti-diabetic medication the previous night.
A higher level above 108 mg/dl (6 mmol/l) when you get up in the morning is a common feature of type 2 diabetes and is actually a puzzle to those who experience it.
Events leading to the Somogyi Effect or rebound hyperglycemia are similar to the Dawn Phenomenon… the difference is the cause. In this case your blood glucose has dropped due to taking too much insulin or failing to have a snack before your bedtime.
Checking your blood sugar levels between 2 and 3am on several consecutive nights will give you a clue as to which effect is the cause of your early morning high sugar level. If your level is consistently low the Somogyi Effect is likely to be the cause. This would then indicate your night-time insulin level is too high or your bedtime snack too small. On the other hand, if your level is high between 2 and 3am, the Dawn Phenomenon is more likely the cause.
Do not hesitate to talk to your health care practitioner as you may need to change the time you take your evening insulin so that its peak action occurs when your blood sugar levels start to rise. Bringing your level down aggressively will only worsen the problem by creating hypoglycemia.
Another theory is that you should be less concerned with blood sugar levels that are elevated in the morning unless there is consistent elevation during the day.
Once your health care provider works out the cause of your high blood sugar levels during the night-time he can advise you as to the changes you need to make.
If you would like to download a free copy of my E-Book, click here now: Answers to Your Questions… it’s based on questions diabetics have asked me recently.
Beverleigh Piepers is a registered nurse who would like to help you understand how to live easily and happily with your type 2 diabetes. http://drugfreetype2diabetes.com/blog
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Control Your Meal Timing And Meal Composition As A Natural Diabetes Treatment
There are natural foods and natural herbs that
will help you to maintain your blood sugar levels
Effective natural diabetes treatment.
It’s not just the foods you eat, it’s also the
percentage of the food groups. It’s eating in a way
that balances your blood sugar levels.
PROTEINS:
1. You only require 4-7 ounces(200 grams), each day.
2. Protein should not cover more than 25% of your
plate and should be lean.
3. When protein is added to a carbohydrate meal the
GI is reduced because it slows down absorption.
4. Spreading protein over your meals will help your
blood sugar levels.
MEAL TIMING:
1. Eat protein for breakfast every day … whole
omega-3 eggs or a protein shake.
2. Eat something every 4 hours to keep your insulin
and blood glucose levels normal.
3. Eat small protein snacks in the morning and
afternoon, eg. a small handful of almonds.
4. Finish eating at least 2-3 hours before retiring.
5. Eat snacks earlier in the day so you will not be
hungry.
MEAL COMPOSITION:
1. By combining adequate protein (25% of meal) and
carbohydrates from vegetables nuts, seeds and
fruit at every meal.
2. It is really important to avoid eating quickly
absorbed carbohydrates (fruit juices containing
sugar, beer, liquers), alone as they really raise
your blood sugar levels.
It is a way of eating that helps prevent and reverse Type
2 Diabetes by turning on the right gene messages.
Knowledge about which foods you should eat and food
combination, is really powerful when you have Type 2
Diabetes.
A Balanced Diabeteic Diet Is Just One Part Of A Natural Diabetes Treatment Plan
In order to achieve normal metabolism in diabetic patients, some form of dietary measures are always recommended. A well balanced diabetic diet is just one part of a balanced natural diabetes treatment plan.
The main aims of diet control are listed below:
1. Avoid hyperglycemia
2. Minimize fluctuations in blood glucose levels and reduce overall blood glucose
3. Achieve weight reduction in obese patients to reduce insulin resistance, hyperglycemia, and dyslipidemia
4. Avoid hypoglycemia and weight gains that are commonly associated with drugs such as insulin
5. Avoid diets that may aggravate diabetic symptoms. For example, diabetic nephropathy may become acute in case of a high protein diet. These diets are known as atherogenic diets in medical parlance.
Two broad classifications of diet used in the treatment of diabetes are low energy weight reducing diets and weight maintenance diets. In the case of obese patients, a diet with low refined carbohydrate, high unrefined carbohydrate and less total energy content would result in increased insulin sensitivity and consequent decline in blood glucose.
Low energy weight reducing diets:
These are diets used for obese diabetic patients. These diets would provide a 500kcal reduction in daily intake and can cause a weight loss of around 0.5 kg per week. In obese diabetic patients it is often advised to skip snacks in between meals.
Weight maintenance diets:
These are for diabetic patients with a normal BMI. These are ideally high in carbohydrate and low in fat. The total calorie intake is not reduced in these diets.
Diets for Insulin Treated Diabetes
Diabetic patients should take care to follow a regular diet pattern and eat meals and snacks at approximately the same time every day. One useful way in which meals can be planned is to encourage the use of carbohydrates along with vegetables and reduce the consumption of proteins. It is recommended to include at least five portions of fruits and vegetables on a daily basis. Children, pregnant women and lactating mothers suffering from diabetes need special dietary advice in consultation with their physician.
An ideal diabetic diet should derive at least 50% of daily caloric intake from carbohydrates and a large portion of this should be dietary fiber. Dietary fiber is mainly of two types – soluble and insoluble. Soluble fiber is present in food items such as beans, peas, pulses, oats and most fruits and vegetables. It is advisable to consume at least 15g of dietary fiber on a daily basis. This can reduce not only blood glucose levels but also LDL cholesterol. Insoluble dietary fiber is found in food items such as whole meal bread and breakfast cereals. These can be a good way to satisfy hunger and manage weight. The insoluble fiber does not lower blood glucose levels directly, though. Sweet food items such as confectionery, puddings, cakes and biscuits should be restricted as much as possible. Milk also is ideally avoided.
Meal Planning Methods
Scientific meal planning for diabetes aims to meet the overall nutrient requirements of the body and keep it healthy; not just lower blood glucose levels. Thus the current lifestyle and eating habits of the diabetic patient must be taken into account before suggesting modifications. Things to keep in mind include work and meal times, food preferences, as well as the goals that the diet plan is aiming to achieve. If there are too many changes needed from one’s current eating patterns then the plan is not likely to be followed. There are some accepted methods of diabetic meal planning and some of them are summarized below
Diabetic Exchange Diets:
In this method, there are six broad types of food based on their micro nutrients – starch, non-starchy vegetables, fats, meat and meat-substitutes, milk and fruits. The daily meal plan is designed to achieve a particular number of servings from each of these areas. Here food is measured in portions and this method is found to be easy to follow. A food exchange chart shows major types of food under each category and the diabetic patient will have the flexibility to replace one food with another from the same list. This variety ensures that there is no boredom generated by eating the same food over and over again. However, care has to be taken to eat the meals at the right time and to limit portion sizes to that recommended by the nutritionist.
The Plate Method:
This is the easiest method to learn. A dinner plate is used as the basis to show proportions of each food group that should be included in the meal. In this method importance is given to vegetables. Raw vegetables should make up at least half of your plate for lunch as well as dinner. The rest can be composed of starch and protein – made up of cereals, bread, potatoes and meat. A single portion of fruit or milk can be had if required.
Pyramid Method:
This is based on the Dietary Guidelines for Americans and aims to provide a well balanced and nutritious diet. It focuses on reducing the amount of fat and sugar without making the diet too monotonous. You can get pyramid meal planners from the internet.
Carbohydrate Counting:
This method is very tedious to follow as the patient needs to count the amount of carbohydrate in take in each meal. The goal is to maintain a low level of carbohydrate in the diet so as to control blood sugar levels. Unless the patient is really committed chances of failure and non compliance are high in this method.
Remember that the three pillars of managing diabetes are diet, exercise and medication. All three of these must be carefully planned and properly adhered to in order to ensure that the patient is able to lead a normal lifestyle without suffering from the complications that arise out of the disease. Ignoring any one of these aspects can cause drastic consequences in the blood sugar levels leading to problems associated with it.
Indian herbs a part of a natural diabetes treatment
Indian Herbs For Natural Diabetes Treatment
1. Bitter Melon (Momordica charantia)
Bitter melon is widely used in Indian medicine as a treatment option for diabetes. It is cultivated extensively in Asia, and parts of Africa and South America.
2. Cherukurinja (Gymnema Sylvestre)
Cherukurinja also known as Meshasringi or Gurmar is popular in India as a “sugar killer”. It is primarily used in the treatment of Type II diabetes. It is a common ingredient in herbal formulas aimed at reducing blood sugar levels. It is also known to have weight reduction properties by reducing the sweet cravings of patients. It increases the ability of the pancreas to produce insulin as well as insulin receptors in cells, thereby helping to control blood sugar levels. Gymnema extract is produced from the leaves of the plant. The leaves are dried and powdered along with coriander; the juice is then prepared and consumed orally for managing high blood sugar levels.
3. Aloe Vera
Aloe Vera is more popular as a herbal remedy for burns and skin diseases, but recent studies point out the possibility of Aloe Vera’s ability to reduce blood sugar levels. A recent Japanese study isolated phytosterol compounds from Aloe Vera gel that could lower blood sugar. In addition glycosylated hemoglobin levels were also found to be controlled with the use of Aloe Vera gel.
4. Cinnamon
Cinnamon is known to reduce fasting blood glucose levels as well as cholesterol levels – LDL, triglycerides and total cholesterol are reduced with as low as 1 g of cinnamon a day. Cinnamon is obtained from the bark of a tropical evergreen tree of the Lauraceae family. It is used as a spice for seasoning curries and other Indian food items. It has other medicinal properties such as its ability to reduce nausea and increase appetite. It is also known to be a cure for gastro-intestinal problems such as gas and indigestion. Cinnamon is known to improve the insulin response of fat cells in the body and can increase the conversion of blood sugar to energy by as much as 200%. It also reduces the formation of free radicals thereby delaying the manifestation of diabetic complications.
5. Indian Kino (Pterocarpus Marsupium)
Indian Kino (Pterocarpus Marsupium) also known as Malabar Kino is a huge deciduous tree normally found in South India and Sri Lanka. It is also known as Pitasara or Venga. It has a proven effect of lowering the glucose absorption from the gastrointestinal tract as well as in increasing insulin levels in the body. It is also known to regenerate pancreatic cells that produce insulin, called beta cells. This regeneration is something no other drug or herbal remedy has been able to achieve. It has been used in India for a long time in the treatment of diabetes. In an experiment in rats, it was found that the epicatechin extracted from the bark of the Malabar Kino was shown to prevent beta cell damage artificially induced by alloxan.
6. Fenugreek (Trigonella foenum-graecum)
Fenugreek can be grown in your house as a herb in a pot. It is vastly found all over China and the Mediterranean areas. Fenugreek leaves as well as seeds are used as a seasoning in most Indian foods. Fenugreek seeds are fiber rich and that is what contributes to its ability to control diabetes. There is another active component in the fenugreek seeds known as trigonelline which has blood sugar lowering properties. Fenugreek is widely cultivated as a crop, and it has other medicinal properties such as ability to improve appetite and manage gastrointestinal problems and skin diseases. It is also known to improve lactation and aid faster healing of wounds and is often an integral part of traditional Indian treatment for women post delivery and as a health supplement for lactating mothers.
7. Gooseberry
Gooseberry or Amla as it is locally known in India, a good source of Vitamin C and has a lot of antioxidants. Traditionally the juice of gooseberry is mixed with bitter gourd juice as a treatment for diabetes. The ratio is typically one teaspoon of gooseberry juice for one cup of bitter gourd juice. The medicinal property of amla is supposed to improve the insulin generation capability of the pancreas. Amla can also be used in powdered form after drying and grounding it. The vitamins are preserved even in the dried form and it is considered a much better source of Vitamin C than grapefruit and lemons. It is also used for treatment of urinary infections as it is known to reduce the body heat. It also reduces body fat and is good for the eyes. Thus it can effectively delay the onset of diabetic retinopathy in patients.
8. Tenner’s Cassia
The flower and seeds of Tenner’s Cassia are found to be effective in lowering blood sugar levels. It can be mixed with honey and consumed daily.
9. Blueberry (Vaccinium Myrtillus)
Blueberry leaves have been traditionally used as a treatment for diabetes. It has an active ingredient called myrtillin that helps to reduce blood sugar levels. It also strengthens the blood vessels and reduces the adverse effects of free radicals in the body. Blueberry leaves are also used in the treatment of diabetic eye diseases. Bilberry is another plant that can lower the risks of diabetic eye diseases such as cataract and retinopathy. Other herbal remedies commonly used in the treatment of diabetes include onion, garlic, gymnema, Momordica charantia and nopal. Leaves of certain plants have been traditionally used in Indian medicine for treatment of diabetic patients. Here is a list of leaves that are commonly used.
10. Leaves of Mango for controlling diabetes
Mango is known as the king of fruits in India. It is consumed in large quantities all over India during the summer months as a tasty fruit. The leaves of the mango tree are used as a treatment for diabetes. The tender leaves are soaked overnight and the next day morning, it is squeezed and filtered out. The water containing the essence of the mango leaves is consumed every morning for reducing blood sugar levels. Mango leaves can also be dried and powdered and consumed in powder form. The recommended dosage is one teaspoon of this powder twice daily.
11. Neem Leaves (Azadirachta indica)
Neem leaves are also well known in India for its anti-diabetic properties. Again, the leaves can be consumed in dried powder form or in the form of juice. The recommended dosage for diabetic patients is typically five ml in the morning. Neem leaves are bitter in taste and diabetic patients may find it difficult to follow this regime. It is usually sweetened with honey, which is not harmful for a diabetic patient despite its sweetness. Diabetic patients should follow this treatment for a prolonged period of time before any noticeable results are obtained.
12. Curry Leaves (Murraya Koenigi)
Curry leaves are typically used as a seasoning in Indian cooking because of its unique flavor. It can be ground with coconut and used as a dip or it can be added to yoghurt as a seasoning. It is also known to aid weight loss, thus obese patients suffering from Type 2 diabetes are often advised to include this in their daily diets.
13. Sweet Potato Leaves
Sweet potato leaves are also extremely beneficial in treating diabetes. However the fruit contains a lot of starch and therefore should be consumed only in very small portion sizes by diabetic patients. Sweet potato leaves can be added along with tea leaves while preparing tea. If used in powdered form then about six teaspoons of powder can be boiled in one cup of water and consumed daily.
Enzymes Are The Key For Your Natural Diabetes Treatments
Enzymes Can hold the secret to diabetes cure? Doctors are not able to reject claims of diabetic cure with enzyme therapy because research has proven that it works wonders and accomplish successful results that normal medicines could never do
What is it anyway? Insulin is basically an enzyme that is secreted by the pancreas. The pancreas also secretes other digestive enzymes. Under diabetic conditions, the insulin level is reduced below the normal level. This is because of improper functioning of pancreas. So it is not just insulin, the level of other digestive enzymes are also drastically reduced.
What happens when the enzymes are reduced, anyway?
- Enzymes are the metabolic force of our body. When enzymes are reduced, the whole biological process of the body screeches to a halt. When enzymes are reduced, the body loses its basic functions and its immunity.
- Reduction in digestive enzymes results in accumulation of undigested proteins in the body. The proteins get accumulated in the kidney and result in major kidney failure.
- Enzymes are the catalyst for absorption of vitamins and minerals. Without enzymes, vitamins and minerals get accumulated without getting absorbed causing dangerous problems.
Enzyme therapy through natural diet supplements the body with the deficient enzymes to give the magic cure for diabetes
When you consume fully processed food containing processed grains, high fat content (we are talking about the bad fat and not the good one that helps the body), it does 2 things to the body:
- Digestive enzymes cannot act on the food that is highly processed. So when the nutrients do not reach the cells, they start to wear out.
- The body never accepts any unnatural intake. This results in the formation of toxins.
But don’t worry. With our selected natural dietary suggestion, you can improve the enzyme levels in the body and yes! You are back on track!!
Can Cow’s Milk Increase Your Diabetic Risk?
Can Cow’s Milk Increase Your Diabetic Risk? Top External Factors That Can Cause Diabetes and affect your natural diabetes treatments plan.
Although the exact cause of diabetes has not been detected, several factors play a role in the manifestation of the disease. It is usually when environmental factors combine with a genetic predisposition that people develop the clinical symptoms of diabetes and this is what determines the timing of onset of diabetes as well. Therefore, even if a person is genetically predisposed to diabetes, proper diet and exercise and a natural diabetes treatments plan can go a long way in preventing the manifestation of the disease. The pattern of heredity and the contribution of environmental factors vary for type I and type II diabetes.
Given below are some of the key contributing factors towards diabetes.
Type I Diabetes
Type 1 diabetes is an autoimmune disease. Hyperglycemia together with other symptoms of Type 1 diabetes occurs only when almost 90% of beta cells in the pancreas are destroyed.
Genetics
If close relatives have Type 1 diabetes, then the chances of getting the disease are much higher than the normal population. This shows that genetics play a role in Type 1 diabetes. The genes that are considered to play a major role in Type 1 diabetes are the HLA class II genes also known as IDDM1 and contribute to almost half of the genetic influence for the onset of type I diabetes. Genetic factors contribute to 30% of the susceptibility of type I diabetes. The region of the insulin gene known as IDDM 2 is also associated with Type 1 diabetes. Other weaker links include IDDM3, IDDM4 and IDDM 5, but more details regarding the actual genes and their mode of action has not been extensively studied.
Environmental Factors
Environmental factors play a bigger role in Type 1 diabetes than genetics. An increased proneness to auto-immune diseases and an impaired immune system can cause Type 1 diabetes.
Viral Infections
Viral infections, especially those affecting the pancreas can cause Type I diabetes. Viral infections even while the child is still in the mother’s womb can cause a higher chance of the baby developing Type I diabetes at a later stage. Specific viruses associated with Type I diabetes are enteroviruses, rota virus, mumps and rubella, as well as cytomegalovirus. Today there are effective vaccinations that can prevent mumps and rubella.
Cow’s Milk
Studies have been conducted on the effect of cow’s milk protein on Type I diabetes. Bovine serum albumin (BSA) a major component of cow’s milk is supposed to play a role in causing Type I diabetes. It has been proven that kids who are given cow’s milk in infancy have a greater chance of developing Type I diabetes than those who are breastfed. BSA can cross the baby’s gut and increase the antibodies which can then cross-react with beta cells in the pancreas thereby damaging them.
Some studies have shown that shorter breastfeeding duration increases the chances of Type 1 diabetes even when there is a genetic predisposition to the disease. Thus if two siblings have close relatives who have Type I diabetes and one of them is breastfed for a longer duration then his chances of developing the disease is significantly reduced. It could also be possible that the absence of a strong immune system in non-breast fed babies is a cause of Type I diabetes. In addition breast feeding ensures the proper development of the gut as well as protects the baby against viral infections that can cause Type I diabetes.
Various other factors such as nitrosamines and coffee are also considered as possible diabetogenic factors. Dietary proteins such as gluten are also supposed to have an effect on Type 1 diabetes.
Hygiene Factor
There is a new theory that being more hygienic can cause Type I diabetes. This theory says that a late exposure to disease causing viruses and bacteria can actually weaken the immune system thus making the body more susceptible to infections at a later stage. This is seen as an explanation of the higher prevalence of Type I diabetes in developed countries. Therefore it is recommended that children attend day cares, share beds with siblings and are allowed to play outdoors and with pets in order to improve their immune system and act as prevention against Type I diabetes.
Stress
Stress can aggravate symptoms of type I diabetes by causing the release if stress hormones which may negatively affect the body’s immune system.
Type I diabetes is also associated with autoimmune diseases such as thyroid, celiac disease, Addison’s disease, pernicious anemia and vitiligo.
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Natural Diabetes Treatment For A Healthier You
Although they are different types of diabetes, natural diabetes treatment is able to suit both conditions. About half the population of adults in middle age will struggle with diabetes and the rate is still increasing. And the consequences are potentially devastating – kidney disease, blindness, and possible death. Naturopathy comprises of a new healthy lifestyle which favors a balanced diet and adequate exercise.
Diabetes is a killer disease and you need experienced professional medical guidance at all times. Some people may be comfortable with their drug medications but there are those who prefer the natural way of treating their illnesses.The term for the process of treating diabetes in natural ways is called naturopathy, which efficiently uses certain natural plants which may ease the diabetic conditions.Some ingredients include balsam pear, bitter melon, garlic, onion, Asian ginseng, bilberry, the extract of ginkgo biloba, cinnamon and barberry.
Today, there are 2 types of diabetes, namely Type 1 diabetes and Type 2 diabetes. Type 1 diabetes is a disease where the body actually destroy the cells in the pancreas, which causes the pancreas to stop producing insulin. People suffering from Type 1 diabetes required the injection of insulin.
While for Type 2 diabetes, your body becomes resistant to the insulin produced by the pancreas. Diabetics have always been advised that reduction of sugar intake is the best relief for their illness. This holds true especially with the usage of the natural treatments presented here. First, having a healthy diet with balance nutrition, and adequate exercise can help to build up your immune system and improve your condition.
North American Ginseng one of the herbs that are good natural treatment for diabetes. It helps to regulate the blood sugar level in your body. It is always advisable to avoid some foods if you are diabetic such as refined sugar, sweets, syrups. Avoid all processed foods, junk food, pastries, cookies, canned and preserved foods.
There are natural diabetes treatments that are optimized for what you need to do to fight diabetes: suppress your appetite, help insulin do it’s job, and attract glucose transporters so the sugar doesn’t float around in your blood. You are what you eat. Watch your diet and you will be halfway through natural diabetes treatment.
Natural diabetes treatment is an art. Chloe Veloso has been studying it for 10 years and has mastered the most effective methods to improve your health conditions. Let her give you the 7 essential tips on how to eat well and live a better life!
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Diabetes The 6 Points That Will Explain It For You
Diabetes mellitus is a chronic disease in which patients present with absolute or relative insulin deficiency. It effects about 6% of western populations and is a major contributing factor for heart attacks, strokes, kidney failure and peripheral vascular disease. Diabetes mellitus is also the leading cause of new blindness.
1. Types of Diabetes
There are four forms of the disease, classified as: types 1 and 2, gestational and other specific types.
a. Type 1 Diabetes
In people with type 1 diabetes the pancreas is not producing insulin, so blood glucose levels are higher than normal. People with this form of diabetes require daily insulin therapy to survive. This form is further split into idiopathic diabetes and immune mediated diabetes.
Type 1 accounts for around 10% to 15% of all people with diabetes. It is one of the most serious and common chronic diseases of childhood, with about half of the people with this form of diabetes developing the disease before age 18. It is also known as insulin dependent diabetes mellitus (IDDM) or juvenile-onset diabetes.
b. Type 2 Diabetes
Type 2 diabetes is marked by reduced levels of insulin (insulin deficiency) and/or the inability of the body to use insulin properly (insulin resistance). This form of the disease is most common among people aged 40 years and over and accounts for 85% to 90% of all people with diabetes. Most people with type 2 diabetes are obese.
c. Gestational Diabetes
Gestational diabetes occurs during pregnancy in about 3% to 8% of females not previously diagnosed with diabetes. It is a temporary form of diabetes and usually disappears after the baby is born. However, it is a marker of much greater risk of developing Type 2 diabetes later in life. Screening tests for gestational diabetes are usually performed around the 24th-28th week of pregnancy.
d. Other Specific Diabetes Types
This includes people who have diabetes as a result of a genetic defect, or exposure to certain drugs or chemicals.
2. Causes of Diabetes Mellitus
Diabetes is caused by resistance to, or deficient production of, the hormone insulin, which helps glucose move from the blood into the cells.
In type 1 immune mediated diabetes, pancreatic beta cell destruction results in failure to release insulin and ineffective transport of glucose. There is no known cause for idiopathic diabetes.
In type 2 diabetes, the beta cells release insulin but, receptors are insulin resistant and glucose transport is variable and inefficient. Some people may have conditions that can cause diabetes, such as Cushing’s syndrome, pancreatitis or liver disease.
Risk factors for type 2 diabetes include;
a. Obesity
b. History of Gestational diabetes
c. Lack of physical activity
d. Hypertension
e. Age 45+
f. Ethnic groupings other than anglo-saxon
g. Low HDL cholesterol levels
h. Impaired glucose tolerance
i. Family history
3. Signs and Symptoms of Diabetes
Symptoms of diabetes include; dehydration, unexplained weight loss, excessive thirst, frequent need to urinate, fatigue, lethargy, severe irritation and itching, excessive hunger, blurred vision, skin and urinary infections and vaginitis.
4. Diagnosis
Diabetes or impaired glucose tolerance may be detected on routine blood tests as part of a general health check up or investigation for other symptoms or diseases. Diabetes tests check blood glucose levels.
Fasting blood glucose levels are classified as:
Normal: less than 100 mg/dl
Prediabetes: 100 to 125 mg/dl
Diabetes: greater than 125mg/dl
Because symptoms can be mild, diabetes is often detected when a person suffers a problem that is caused by diabetes, such as a heart attack, stroke, neuropathy, poor wound healing or a foot ulcer, certain eye problems, certain fungal infections, or delivering a baby with macrosomia or hypoglycemia.
5. Diabetes Treatment
Effective treatment endeavors to normalize blood glucose and reduce complications using insulin replacement, diet and exercise. For those with very mild diabetes, diet plus weight loss plus exercise may be enough to keep blood glucose within reasonable levels.
Dietary changes should focus on the ideas of weight loss and blood sugar regulation by keeping the blood sugar levels relatively stable throughout the day, avoiding big peaks or troughs.
The principal treatment of type 1 diabetes, even from its earliest stages, is replacement of insulin combined with careful monitoring of blood glucose levels using blood testing monitors.
Type 2 diabetes may require oral anti-diabetic drugs to stimulate body insulin production and increase insulin sensitivity. Various forms of natural supplements for diabetes treatment have also been postulated as effective.
People with unstable diabetes, or those requiring many injections a day, may benefit from an insulin pump which is worn on the body and delivers a continuous infusion of insulin via a needle implanted into the body.
Gestational diabetes is fully treatable but requires careful medical supervision throughout the pregnancy. Even though it may be transient, untreated gestational diabetes can damage the health of the fetus or the mother.
Treatment for all forms of diabetes need not significantly impair normal activities, if sufficient patient training, awareness, appropriate care, discipline in testing and dosing of insulin is taken
6. Complications
Diabetes mellitus is the most common cause of adult kidney failure worldwide in the developed world. If undetected or poorly controlled, diabetes can lead to blindness, kidney failure, lower limb amputation, heart attack, stroke and impotence.
Dick Aronson has a background of over 35 years in various facets of the Healthcare industry. He set up and ran clinical trials in more than 20 countries and he has also founded a number of small private health related businesses. Dick now runs a number of informative health websites Go to Health Innovations Online and he has a herbal health store at Visit the Herbal Health Store
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The Truth About Diabetes
Like all complicated matters there are certain misunderstandings regarding Diabetes.
Today I want to dispel some myths regarding diabetes.
Here is a list of the questions that I will be discussing:
Can get diabetes from someone else?
Eating too much sugar causes diabetes
Type 2 diabetes is mild diabetes
People with diabetes eventually go blind
It’s not safe to drive if you have diabetes
People with diabetes can’t play sport
People with diabetes are more likely to get colds and other illnesses
People with diabetes can’t eat sweets or chocolate
People with diabetes shouldn’t eat bananas or grapes
People with diabetes should eat special diabetic foods
Now for some serious myth bashing…
Can get diabetes from someone else?
Although we don’t know exactly why some people get diabetes, we know that diabetes is not contagious – You cannot get it from others. There is a chance that a person whose parents or brothers and sisters have diabetes might get diabetes, particularly Type 2 diabetes. But lifestyle factors also play a part.
Eating too much sugar causes diabetes
Eating sugar does not cause diabetes. Diabetes is caused by a combination of inherited and lifestyle factors. However, eating a diet high in fat and sugar can cause you to become overweight. Being overweight increases your risk of developing Type 2 diabetes, so if you have a history of diabetes in your family, a healthy diet and regular exercise are recommended to control your weight.
Type 2 diabetes is mild diabetes
There is no such thing as mild or borderline diabetes. All diabetes is equally serious, and if not properly controlled can lead to serious complications.
People with diabetes eventually go blind
Although diabetes is the leading cause of blindness in people of working age, research has proved you can reduce your chances of developing diabetes complications – such as damage to your eyes – if you:
• Control your blood pressure and glucose levels
• Keep active
• Maintain your ideal body weight
• Give up smoking
It’s not safe to drive if you have diabetes
Providing you are responsible and have good control of your diabetes, research shows that people with diabetes are no less safe on the roads than anyone else. Nevertheless, the myth that people with diabetes are not safe persists
People with diabetes can’t play sport
Pakistan’s famous all-rounder Wasim Akram has diabetes; many other people with diabetes take part in active sports. People with diabetes are encouraged to exercise as part of a healthy lifestyle. Keeping active can help avoid complications associated with diabetes, such as heart disease. There may be some considerations to take into account with your diabetes before taking up a new exercise regime – talk to your doctor for more information.
People with diabetes are more likely to get colds and other illnesses
No. You are no more likely to get a cold or another illness if you’ve got diabetes. However, people with diabetes are advised to get flu vaccinations. This is because any infection interferes with your blood glucose control, putting you at risk of high blood glucose levels and, for those with Type 1 diabetes, an increased risk of ketoacidosis.
People with diabetes can’t eat sweets or chocolate
Sweets and chocolate can be eaten by people with diabetes just like the rest of us, if eaten as part of a healthy diet. Remember that confectionery foods tend to be higher in fat and calories too so for this reason they should be limited especially if you’re trying to lose weight.
People with diabetes shouldn’t eat bananas or grapes
All fruit and vegetables are extremely good for you. Eating more can reduce the risk of coronary heart disease, some cancers and some gut problems. You should aim to eat at least five portions of fruit and vegetables a day. This also helps to improve the overall balance of the diet. Eating a variety of different fruit and vegetables ensure you get the maximum benefit.
People with diabetes should eat special diabetic foods
Diabetic versions of foods offer no special benefit. They still raise blood glucose levels, contain just as much fat and calories, are usually more expensive and can also have a laxative effect. The healthy diet for people with diabetes is the same as that recommended for everyone – low in fat, salt and sugar, with meals including starchy foods like bread and pasta and plenty of fruit and vegetables.
Dr Sherry Chandy is a Medical Domain Specialist at Yos Technologies.
He is a medical doctor and ophthalmologist by profession and has special interests in enabling better health care through the use of information technology.
For more such useful information and diabetes care tools which help you to Control Diabetes effectively and to see a video of me explaining the six steps to control your blood sugar levels go to
http://diabetescare.yoscare.in/diabetes_information
Type Of Diabetes
Different Type of Diabetes
There are many types of diabetes, but the three most common are:
1. Type 1
2. Type 2
3. Gestational
These three types of Diabetes are same with some differences, everyone with diabetes has one thing in common and that is little or no ability to move glucose out of the blood into the cells, where it is converted into body’s primary fuel. We all have glucose in our blood, whether or not we have diabetes. Main source for glucose is food which we eat. When we eat, the digestive system breaks down food into glucose, which is absorbed into the blood in the small intestine.
People who don’t suffer from diabetes depend on insulin, a hormone made in the pancreas, to move glucose from the blood into the body’s billions of cells. But people who suffer from diabetes either don’t produce insulin or can’t efficiently use the insulin produced in their body. Without insulin, glucose can’t move into blood cells. Scientists don’t know the exact reason behind cause’s diabetes, but it seems to be a result from a combination of genetics and environmental factors, including viral infections, poor diet, and sedentary lifestyle. Till now, diabetes has no solution, but the good news is that the disease can be managed and treated. People with diabetes can live fulfilling, healthy lives.
Type 1
Diabetics with type 1 diabetes, also known as insulin-dependent diabetes mellitus or IDDM don’t produce insulin and require regular supply of insulin to keep their blood glucose levels normal. Type 1 diabetes was known as juvenile-onset diabetes, but that name has been changed because type 1 diabetes also strikes young and older adults alike.
Risk factors
A family history of the diabetes increases risk for next generations.
Diabetes can happen in people of every society, but it’s most common among whites.
Half of type 1 diabetics are under the age of 20. Being age 20 or younger increases the risk.
What causes it?
Most of the children, whose parents are diabetics, do not suffer from this disease, but scientists still believe that heredity plays a big role in Type 1 diabetes because it tends to run in families.
Researchers have researched on several genes that appear to increase risk of type 1 diabetes. But they haven’t got a single gene that causes diabetes.
Type 1 diabetes has many hallmarks of an auto-immune condition. In auto-immune diseases, the immune system, this protects from disease by killing invading germs. In the case of type 1 diabetes, the immune system kills the cells in the pancreas that produces insulin.
Type 1 diabetes often occurs shortly after a viral infection, and doctors sometimes notice a sharp jump in type 1 diabetes diagnoses after viral epidemics.
Type 2
Approximately 95 % of diabetics suffer with type 2 diabetes which is also known as non-insulin-dependent diabetes mellitus or NIDDM. Type 2 Diabetics produces insulin, but the cells in their bodies are “insulin resistant” they can’t respond properly to the hormone, so glucose is accumulated in their blood. Some people with type 2 diabetes inject insulin, but mostly can control the disease through a combination of weight loss, exercise, a prescription oral diabetes medication, and tight control.
Risk factors
Similar to Type 1, Type 2 disease also runs in families and increase the risk for upcoming generations.
Most of the diagnosed people with type 2 are above of age 30 or older. Half of all new cases lie between age 55 and older.
In comparison of whites and Asians, type 2 diabetes is more commonly found among Native Americans, African-Americans, Latinos, and Hispanics.
Insulin resistance results in increment of weight and decrement of physical activities. Most of the people suffering from type 2 diabetes have sedentary lifestyles and are obese; there weight increases at least 20 percent more than the recommended weight according to their height and build.
Less exercise, especially for those who are overweight, increases the risk for diabetes.
If a female developed gestational diabetes during pregnancy, she is at a higher risk of type 2 diabetes later.
Females who have given birth to babies weighing 9 pounds or more are at an increased risk of Type 2 Diabetes.
What causes it?
Scientists are not sure, but type 2 diabetes, like type 1 diabetes, flows from families to families, which shows some genetic connection. In fact, a genetic link in Type2 diabetes seems even stronger in comparison with type 1. Scientists have not yet found a single gene that causes the disease, but they are still in search for errors in several that may contribute to the disease. Researchers also have a doubt on genetic susceptibility to obesity.
Obesity is the only single most important cause of type 2 diabetes. There are different definitions for obesity, but in general, Obesity occurs if a person’s weight is at least 20 percent more than what’s recommended according to their height and build. 75% of people with type 2 diabetes have problem of being overweight. That’s why type 2 diabetes is usually linked with diet and exercise.
Less weight and good muscles helps the body use insulin more effectively. This is very important to know how much weight we should carry. People whose weight is above their hips have a greater risk of developing type 2 diabetes than those who carry it on their hips.
Age also plays an important role in type 2 diabetes. Most of the newly diagnosed are of age 55 and above, and around 11 percent of Americans ages 65 to 74 suffers from type 2 diabetes. However, it is not sure if age is a cause of type 2 diabetes or it is simply a reflection of the fact that people tend to gain weight and become less physically active as they grow older.
Gestational
Gestational diabetes affects only to pregnant ladies without any previous history of diabetes. Nearly 137,000 U.S. females develop gestational diabetes each year.
Typically, gestational diabetes is cleared up on its own after female’s delivery. But research shows that about 40% of females with gestational diabetes face type 2 diabetes within 15 years. All pregnant ladies should be tested for gestational diabetes between their 24th and 28th weeks of pregnancy.
Gestational diabetes and insulin resistance can be prevented by keeping a healthy weight, having healthy food and with the help of regular exercise.
Risk factors
Diabetes problem flows from generation to generation.
Increase in weight, increases insulin resistance.
Native Americans, African-Americans, and people of Hispanic or Latino descent are at increased risk. Whites and Asians have a lower risk.
What causes it?
Hormones may play an important role. Pregnant ladies produce various hormones important for their baby’s growth. However, these hormones may interfere with the mother’s body’s ability to properly use insulin, causing insulin resistance.
Every pregnant lady has some degree of insulin resistance. But if this resistance becomes full-blown gestational diabetes, it usually appears around the 24th week of pregnancy. That’s why all pregnant ladies should be screened for gestational diabetes at that time.
Prashant Jain
SEO
To Compare the Role of Glibenclamide and Pioglitazone Drugs in Type 11 Non Insulin Dependent Diabetes Mellitus Patients
To compare the role of glibenclamide and pioglitazone drugs in type 11 non- insulin dependent diabetes mellitus patients.
Authors:Raj kumar chohan,Mashori Ghulam Rasool,Bhurgri Ghulam Rasool,Shamim-u-Rehman,DahriGhulam mustafa,Anis-u-rehman.
Introduction:-
Diabetes comes from the greek word for ‘SIPHON” which one is the first term and implies for a lot of urine is made .The trm “mellitus” comes from a laton word, “met” which means “honey” and was used because the urine was sweet (Wheeler,2004)
Diabetic ketaocidosis is one of life threatening condition requiring some data hospitalization and treatment. Recognition of this condition is of almost importance, because even small delays can have an impact on survival (Nattrass, 2006). Hypoglycaemia are involved in insulin induced episodes in individuals with diabetes. Probably the major factor prescribing, insulin treated patient from achieving the glucose targets needed to prevent diabetic complications. The incidence of hypoglycaemia reflects the inadequancy of current mathods of insulin delievery which lead ot inappropriately high insulin concentration, particularly some persons after eating more foods at night onset of blindness and also a major risk factor heart disease and stroke
(Heller, 2003).
TYPES OF DIABETE MELLITUS
TYPE 1 DIABETES MELLITUS (IDDM):
Type I diabetes affect children of all ages, both sexes and all athenic groups. type 1 diabetes usually occurs by mechanisms. It is most common metabolic condition in children and adolescents (Bui, 2004). Type1diabetes is characterized by immune mediated destruction of pancreatic b -cells resulting in insulin deficiency. This results in a common biochemical end point of hyperglycaemia and risk of ketoacidosis, but the clinical presentaion varies, widely depending on the rate and degree of b -cells failure (Lambert & Bingley. 2005).
Type II diabetes mellitus (NIDDM):
Type II diabetes is a complex metabolic disorder associated with, b -cells dysfunction and with varying degree of insulin resistance primary pathogenic factors leading insulin resistance leading to type 2 diabetes and decreased insulin, secretion which arise from abnormalities with in liver, skeletal muscle and pancreatic b -cells (charles & clark, 1996).
GESTATIONAL DIABETUS MELLITUS
:
Women who develop glucose intolerance in late pregnancy and womens who with previously undiagnosed diabetes.
SECONDARY DIABETUS MELLITUS:
Secondary diabetes is due to disease of the pancreatic and endocrime system, genetic disorders, or exposure to chemical agents.
Type – I diabetes formerly known as insluin dependent diabetes mellitus (IDDM), is characterized by the destruction of the pancreatic beta cells that produces inslulin
Type – I diabetes formerly known as insulin dependent diabetes(IDDM),is characterized by the destruction of pancreatic beta cells that produces insulin.Type-1 diabetes occures most often in children and young adults but it can occures at any age.(Anderson et al 2007).
Type-11 diabetes is not straight uprward. A pancreas that does not produce enough insulin. Liver that release too much glucose,muscle cells that do not readily take in glucose.(Carren 2008)
Many genetic factors are involved in the development of diabetes.Because of new genetic methodology researchers are closers to identifying all of the cadidate gene for both non –insulin dependent and insulin dependent diabetes(Bernhard,1995).
Woman who had gestation diabetes are more likely to develop Type-11diabetes themselves.Pergnant women with diabetes are another disadvantaged group.They need much more intensive antenatal care and close monitoring of blood sugar,blood pressure and weight.(jawed2006)
Over weight children the progression of child obesity into adulthood is associated with early develop of complications, including IgpG2 diabetes and cardiovascular disease.Type diabetes is the most common clinical form of diabetes accountingforabout 90% of all cases,it is currently undergoing world wide epidemic. Type 11diabetes mellitus is caused by body’s infective use of insulin, it is often results from excess body weight and physical inactivity(WHO 2007).
PREVALACES& IINCIDENCE
:
Diabetes mellitus increases with aging, in 200 the prevalance of diabetes,it was estimated to be 0.19% people<20 years old and 8.6% in people>20 years old.There is considered geographic variation in the incidence of both type-1 and type-11 diabetes mellitus.Scavandinvian has the highest incidence of type-1 diabetes mellitus e.g in Finland, the incidence is 35/100,000 per year the pacific rim has a much lower rate in japan and china the incidence is 1 to 3/100,00 per year of type-1 diabetes mellitus, Northern Europe and the United States share an intermediate rate (8to17/100,000 per year).The prevalence of type 11 diabeties mellitus is highest in certain pacific island, intermediate in countries such as India and the United States, and relatively low in Russia and China.This variability is likely due to genetic, beharioral and enviromental factors(Power 2005).Diabettes mellitus prevalance also arises among different ethic population within a given countries it is common inall ethnic groups its prevalance increased with age and more than 5% of individuals of more than 65 years of age have diabetes mellitus (David Owerback 1988).The World wide prevalence of diabetes mellitus has risen dramatically over past two decades.The prevalence of type11 diabettes mellitus is expected, type 11 diabetes mellitus is more prevalent among Hispanies Native Americas,African,American,and Asians, pacific Islanders than in non- Hispanic whites,the incidence is essentially equal in woman and men in all populations. Type 11 diabetes is becoming increasingly common because people are living longer,and the prevalence of diabetes increases with age it is also seen more frequently now than before in young people, in association with the rising prevalenceof childhood obesity although type11 diabetes still countries with the estimated nubers of cases of diabetes in 2000and 2030.
Rank Country
2000 Individuals country with diabetes (milloins)
Country
2030 Individuals with diabtes (Million)
India
31.7
India
79.47
China
20.8
China
42.3
USA
17.7
USA
30.3
Indonesia
8.4
Indonesia
21.3
Japan
6.8
Pakistan
13.9
Pakistan
5.2
Brazil
11.3
Russian federation
4.6
Bangladesh
11.1
Brazil
4.6
Japan
8.9
Italy
4.3
Philippines
7.8
Bangladesh
3.2
Egypt
6.7
(Wareham& FOROUHI 2OO6)
DRUG TREATMENT OF DIABETIES MELLITUS
:
Biguanides lower blood glucose, they increase glucose uptake and utilize in skeletal muscle there by reducing insulin resistance, and reduce hepatic glucose production (gluconeogenesis).Lower blood glucose, addionally reduces low denisity and very low denisity lipoproteins (LDL and VLDL) respectively. Metformin has a half life of about 3 hours and is excreted unchanged in the urine.Clinically metformin used in type 2 diabetic who are obese and who fail treatment with diet alone.Adverse effects are produced dose related gastrointestinal disturbances e.g anorexia,diarrhoea,nausea,lactic acidosis rare but potentially fatal toxic effect.(Dale,2003).
Improving insulin sensitivity by activating certain genes involved in fat synthesis and carbohydrate metabolism Rosigilitazone and Piogiltazone are currently approved.Thiazolidinediones. Thiazolidinediones do not cause hypoglycemia when used alone,although they are usually taken in combination with sulfonylurease.
In some incouraging studies, thaiazolidiniones have produced very favorable effects on the heart, including reducing blood pressure and improving triglycerides and cholestrol levels including increasing HDL level,the good cholestrol. They may also block a molecule called 11 Best HSK that may play a significant role in metabolic syndrome,as well as diabetes type11. One study also sugessted that Rosiglitazone may even improve beta cells functions and so help prevent progression of diabetes.Anemia, weight gain, increased risk of fluid buildup, may worson heart failure.Troglitazone,was withdrawn after a few reports of heart failure.Liver failure abd death.Current Thiazoldinediones don not appear to pose the same effects on the liver although there have been a few reports of liver injury.
In patients with dietry failur the choice of a sulfonylurea agent or insulin therapy has been controversial and empric in favour of insulin therapy are the studies, who reported marked improvement post receptor diagnostic after intensive short term therapy in untreated type 2 diabetes mellitus (Scarlett et al,1984) Sulfonylureas further classified into two groups or generations based on their potency,duration,drug interaction,side effects profiles. Sulfonylureas enhance insulin action in cells in culture and stimulate the synthesis of glucose transporters (Jacobes et al 1998).A sulfonylurea drug should normally be the insulin secretagogue of choice, NICE (National Institute for Clinical Excellence) also recommends that a generic ,drug should be perscribed (Scsade et al1998).
RESEARCH DESIGN AND MATERIAL AND METHODS:
This study was conducted in the deprtment of Pharmacololgy and Therapeutics,Basic Medical Science Institute,Jinnah,Postgraduate Medical Centre,karachi under kind supervision od DRr:GhulamRsool Mashori,Associate Professoer and Head OF Department Of Pharmacology and Therapeutics in colloboration with Medical Outpatient Department Unit111 and Filter Clinic, Medical Department, JPMC,Karachi.
Seventy NIDDM (type-II)diabetic patients were initially enrolled in the study from the filter clinic/ out patient department Medical Unit III ,and diabetic clinic.Out of this 60 diabetic patients were associated in whole period of study, remaining 10 patients were dropped due to poor comlpiance or change in residential place.All the patients were divided in two main groups,groupI and in group II these patients were selected in this study according of inclusion and exclusion criteria.
INCLUSION CRITERIA
:
Newly diagnose patients of non Insulin Dependent Diabtes Mellitus.
Diagnsed patients of diabetes also including having no any history medication.
Having either sex of age between 30 to 60 years.
Diagnosed patients who were Non Insulin Depedent Diabetes Mellitus who were treated with Pioglitazone.
Diagnosed patients who were Non Imsulin Depedent Mellitus, who were treated with drug Glibenclamide.
EXCLUSION CRIRERIA
:
Patients suffering from blood pressure.
Patients suffering from liver disease.
Patients suffering from cardiac disease.
Pregnancies and lactating women.
Patient suffering from renal disorders.
Patients having serious complications.
MATERIAL:
Lacets.
Lancet Hlder(Abbots easy touch TM2 lot 03 Asee).
Glucometer(Medisense) optilim one touch(Abbotts).
Blood glucose nest trpis (IVD for Invitro diagnostic use (Abbott Labortries,Medisense UK Ltd,Abigngdon,Ox14ITR,Masde in UK). Stored between minimum 30?, (4°-30° C) and Maximum 40°C (39°-86°F).
Weight Machine Model No 1101 Lot No.312. TANTIATA.
DRUGS
Tab:Daonil 5 mg (Aventis Pharma)
Drug category:Sulphonylurea.
Generic Name: Glibenclamide.
MFGLIC:No.000007 RegistrationNO.000220
MFG Date:0-06
EXP Date:7-10
Lot NO:B230
Tab:piozer (Hilton Pharm) PvtLTd.
Tab:Poizer 15mg
Drug category:Thaiazolinedione.
Generic Name:Pioglitazone Hydrochloride.
MFG LIC: O.000136 Registration No.03270
MFG Date:3-06
EXP Date:3-o9
Lot No:6287
Tab: Poizer (Hilton Pharma)pvt ltd.
PARAMETERS:
Fasting Blood Sugar (FBS).
Random Blood Sugar (RBS).
Weight.
Key words:Diabetes mellitus,Non-insulin diabetes mellitus,Insulin depedent diabetes mellitus, Daonil,poizer,Insulin.
RESULTS:
Table 1
Weight and Blood Sugar level observed on baseline day 0
In group1 and group11
Group 1
Group 11
Pioglitazone n=27
Glibenclamide n=33
Weight
63.37
+ 2.25
¯
62.7
+ 15.56
¯
Fasting Blood Sugar
172.7
+ 13.32
¯
188.42
+ 12.o5
¯
Random Blood Sugar
285.11
+ 15 .532
¯
284.18
+ 17.07
¯
All Values are expressed in Means± SEM.
FIGURE-1 weight and blood sugar levels observed on baseline (day-o)
In table No shpwing the weight (KG’S) and blood sugar (msg/dl0 levels which is observed on baseline (day-0) in both groups 9group: 1 & group11)
Group: 1 Weight in (Kg’s) mean + SEM) IS 63.37±2.25 Fasting blood sugar 172.7±13.32,and Random
blood sugar 285.11±15.32
Group:11
Weight (KG’s0 (mean +SEM)62.7±1.56 Fasting blood sugar (mg/dl0 188.42±12.05, Random blood sugar is 284.18±17.03.
Figure 2: showing the weight and blood sugar levels observed in base line (day-0) in group: 1 and group 11 weight in 9kg’s) its mean values are 63.37,62.7, Fasting blood sugar in (mg/dl) is 172.71, 188.42 Random blood sugar (mg/dl) is 285.11 &284.18.
TABLE: 2
Peroidic Observation In All Parameters Group1
Goup1(Pioglitazon) n=27
P-value
Day-0
Day-45
Day-90
Day-0to45
Day-45-90
Weight
63.37
±2.25
63.63
±2.26
63.63
±2.23
>0.05
(NS)
>0.05
(NS)
Fasting blood sugar
172.7
±13.32
165.04
±8.98
153.37
±7.59
>0.05
(NS)
0.05
(NS)
Randomblood sugar
285.11
±15.32
279.78
±13.63
255.56
±12.65
>0.05
(NS)
>0.05
(NS)
All values are expressed in Mean±SEM .(NS) Non significant.
TABLE NO:2
Showing the periodic observations in all parameters in group 1 (piogiltazone) (n+27) weight P.value (day 0 to day 45)>0.05 (NS). Fasting blood sugar >0.05 (NS) Random blood sugar >0.05 (NS) P.values day 90 weight >0.05 (N.S), FBS>0.05 (N.S) 7RBS >0.05(N.S) NON SIGNIFICANT
FIGURE:2 Showing the periodic observation in all parameters in group 1 on day0 day 45& day-90.Mean values in weight (Kg) is 63.37,63.26,63.63, fbs (mg/dl) 172.7,165.04,153.37,RBS(mg/dl) 285.11,279.78,255.56.
TABLE NO3
Peroidic Observation in All Parameters Group11
Group 11 (Glibenclamide)
N=33
P-value
Day-0
Day-45
Day-90
Day-0 to 45
Day-45 to 90
Weight
62.7
±1.56
65.64
±2.10
64.55
±1.92
>0.05(NS)
0.05(NS0
Fasting blood sugar
188.42
±12.05
168.45
±10.99
140.06
±5.68
>0.05(NS)
>0.05(S)
Random blood sugar
284.18
±17.03
220.12
±13.39
170.94
±5.80
<0.005 (MS)
0.002(MS0
(s) significant, (MS) moderate significant
All values are expressed in Mean±SEM.
Table No3:
Showing the periodic observation in all parameter in goup:11, Group:11 containing drug (Glibenclamide),no of patients (n=33).It’s P-value on day 0 to day 45 on weight >0.05(NS),FBS>0.05(N.S) RBS<0.005 (MS) <0.01- AND DAY 45 TO DAY 90 WEIGHT >0.05 (NS) FBS (0.05) RBS <0.002(M.S0 moderately significant.
Figure 3:Shwing the periodic observations in all parameters in Group 11 weight 62.7,65.64,64.55,FBS (MG/DL) 188.42,168.45 140.06,RBS(mg/dl) 284.18 220.12, 170.94 (on day-0-day 45 to 90).
DISCUSSION:
In Denmark Beck-Nielsenet al,skillman TG (1981) published studies demonstation that glyburide increased he number of receptors on the monocytes of patients with type 11 diabetes mellitus. Some patients were treated with diet and in cobination of second generation sulfonyureas agents Wie. The numbers of insulin receptors all patients were measured before and after the treatment.Intrvenous glucose test shows the persistent impairent of insulin secretion afterthe starting of drug therapy.However those patient who were on drug Pioglitazone some results were obtained of insulin secretion in the impairment in early drug drug therapy.Clinical observations have suggested that the second generation sulfonylureas may exert their effects by potentiating insulin released by other primary stimulators Insulin secreting drug.
According to the study of WilliamC Dukworth et al(1972), aftr the chronic treatment with sulfonylureas it is well documented that plasma insulin levels were decreased in response to oral glucose load. This apparently occures even though glucose tolerance is improved over pre-treatment, levels,present study clearly support that study.
The result og group 11 correlates with the research conducted by Bonnie &Kimmel (2005) produces the same results as FBS reduces from baseline, and at the end of study,with an overall 23.44%,reduction,while with the results showed at the end of study peroid p-value were (p<0,001).
Similarly Michael Alvarsson et al (2003) conducted a similar type of study and the found and overall changes of change of 22.11% in Fbs and 40.88% in Rbs at the end of trial p-value were (p<0.001).
However a study conducted by (Stone &Brown in (2003) didnot match to our results in the parameter of FBS and observer a reduction of 26.22%.
CONCLUSION:
In the light of study discussion it is obiovus the glibenclamide was more effective,tolerable and safer than pioglitzone in a short duration.Diabetes Mellitus is chronic prolong disease for whole life.Poor community can afford it easily,on base of marketing of this drug in pakistan diabetes patients easily go and purchase economically,in fact ,mostly people buy it from pharmacy without dr’s perscription,because pharmacist and patient both of know about this disease.Just like dispirin as analgesic,it is famous anti-diabetic drug in our states as compared of other anti-diabetic drugs.
REFERNCES:
Anderson J,Kendall,Perryman.S etal,”Diet and Diabettes” Diabetes 2006,16(3):17-19-
Bui H- Type 1 diabetes in childhood-Medicine 2006,3 ,1-3
Bernhard –Diabetes-type 11 diabetes mellitus Diabetes care 1995,19(100:12-17-
Clark CM-Oral therapyin type11 diabetes-pharmacological properties and clinical use of current use of currently available agents-Diabetes spectrum 1998,11(4):211-221.
Carren M.Types of Diabetes mellitus-Diabettes 2006 10 (3),07-
David Owerback NJ-Prevalence in diabetes population-Diabetes 1988,02(6):31-32
Dale MM,-Treatment of Diabetes mellitus –pharmacology 20035th edition:287-391.
Heller SR –Hypoglycemic in diabetes Ketoacidosis and hypoglycemic-Medicine 2006:34(03):102-110.
Jawad F Untraveling the mystry of Diabetes’Diabetes 2006;15(3):13-15.
Jacobes D-Insulin-Diabetes 1998;6(3);1160126.
Lambert and Bingliy-basic facts-medicine 2006,34(6):3-7.
Natters M-Ketoacdosis and hyperglycemia-Medicine 2006;34(3):104-106.
Power AC-Epidemiology of type11 diabetes Basic facts of diabetes –Diabetes 2005;1(1)7-9
Scarlet Oral therapy in type 11 diabetes sulfonylureas 1984;16(10);3-9.
Schade DS et al A placebo controlled randomized study of glimepiride in patients of Diabetes mellitus- Diabetes 19998, 38(7);636-641.
Warchman and Forouhi-Epidimology of Diabetes- Diabetes basic facts- Medicine 2006 ;34(2);57-60
Wheeler Gd- Aaccident dicovery led to the noble prize for canadian reseachers,2005,01-02.
WHO Report-Health-Diabetes Mellitus-Defiition and types of Diabetes 2007;1:1-4.
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FactoryReconditioned Waring JEX328FR Health Juice Extractor
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Editor's note: This is a reconditioned small appliance. Reconditioned generally means that the appliance has been returned to the manufacturer, who brings the appliance back to like-new condition. Some appliances may contain cosmetic blemishes. ....read more
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Cook N Home 9.5 Quart Stainless Steel Juicer
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